Steven C. Pageau, Ph.D.
Dr. Pageau’s practice includes U.S. and foreign patent preparation, prosecution, and strategic counseling across a range of scientific and technical areas, including immunology, virology, and biologic medical products and devices.
His scientific background is in the field of cellular and molecular biology with particular emphasis and experience in immunology, calcified tissue biology, cancer biology, in vivo delivery of small interfering (si) RNAs, tissue engineering, and three-dimensional (3D) cell culture models.
Dr. Pageau’s thesis studies focused on the development of a 3D model of the human conducting airway for the study of respiratory diseases. His research revealed the importance of the bronchial stroma in the pathogenesis and progression of lung cancer. Using histological, biomechanical, biochemical and gene expression analyses, he demonstrated that cellular and acellular components of the bronchus act synergistically to promote a neoplastic phenotype. In addition to this work, he has experience in the development and tissue-specific delivery of therapeutic siRNAs and cancer immunotherapeutics. His immunology research involved studies of T-cell mediated immunity and the engineering of humanized therapeutic antibodies.
- Boston Patent Law Association (BPLA)
- Massachusetts Biotechnology Council (Mass Bio)
- American Association for the Advancement of Science (AAAS)
- Society for Biomaterials
- Peer reviewer for Journal of Clinical Interventions in Aging
- Admitted to practice Veterans law before the United States Court of Appeals for Veterans Claims (CAVC)
- First Author. “The effect of stromal components on the modulation of the phenotype of human bronchial epithelial cells in 3D culture,” Biomaterials, 2011.
- First Author. “Denosumab,” mAbs, 2009.
- Coauthor. “Phenotypic analysis of Dlx5 overexpression in post-natal bone,” Journal of Dental Research, 2008.
- Coauthor. “Antibody treatment of human tumor xenografts elicits active anti-tumor immunity in nude mice,” Immunology Letters, 2007.
- Coauthor. “Autoregulation of bone sialoprotein gene in pre-osteoblastic and non-osteoblastic cells,” Biochemical and Biophysical Research Communications, 2004.
- Coauthor. “Bone sialoprotein promotes bone metastasis of a non-bone-seeking clone of human breast cancer cells.” Anticancer Research, 2004.
- Coauthor. “Regression of human colon cancer xenografts in nude mice by treatment with antiserum,” FASEB Experimental Biology, 2001.