David F. Cauble, Ph.D.

David Cauble is a technology specialist with a focus on chemistry, biotechnology, and pharmaceuticals. He has experience in patent preparation and prosecution, freedom-to-operate and patentability analyses. He is currently pursuing his juris doctorate at Suffolk University Law School, with an expected graduation in 2014.

Dr. Cauble is an organic chemist with experience in both academic research and drug development in the pharmaceutical industry. He assists clients with patent preparation and prosecution. As a senior scientist at Schering-Plough Research Institute, his studies involved exploration of biological pathways implicated in cancer through the discovery and application of small molecule protein kinase inhibitors. Dr. Cauble is also an inventor and co-author on six U.S. patents that detail the application of liquid carbon dioxide-based technologies within the textile industry.

Dr. Cauble’s notable experience includes:

• Assisting with the preparation and prosecution of U.S. and foreign patent applications in the fields of small molecules, biologics, synthetic methods, drug delivery compositions, polymers, materials science, and medical devices.
• Conducting freedom to operate analyses and drafting infringement and invalidity opinions.
• Postdoctoral research at Stanford University, in the labs of Professor Barry Trost, advancing the syntheses of the marine macrolide (-)-dactylolide and the diterpenoid glycoside cotylenin A.

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• Graduate research in the labs of Professor Michael Krische, leading to the development of novel synthetic methods, including an enantioselective, organocatalytic photocycloaddition and the discovery of a catalytic, anion radical-mediated [2+2] cycloaddition. 

Dr. Cauble’s prior experience includes serving as a Senior Scientist, Medicinal Chemistry at Schering-Plough Research Institute; a Postdoctoral Associate at Stanford University in Professor Barry Trost’s labs; a Graduate Research Assistant at the University of Texas at Austin in Professor Michael Krische’s labs; and a Chemist at Micell Technologies. 

Professional Affiliations

• American Chemical Society

Publications

• Contributor to seven peer-reviewed research articles published in the Journal of the American Chemical Society, the Journal of Organic Chemistry and Tetrahedron
• Yang, J.; Cauble, D. F.; Berro, A. J.; Bauld, N. L.; Krische, M. J. “A Mechanistic Dichotomy in the Reaction of Gilman Reagents with Conjugated Enones: Partitioning of Electron Transfer and Conjugate Addition Manifolds,” J. Org. Chem. 2004, 69, 7979
• Agapiou, K.; Cauble, D. F.; Krische, M. J. “Copper Catalyzed Tandem Conjugate Addition-Electrophilic Trapping: Ketones, Esters and Nitriles as Terminal Electrophiles,” J. Am. Chem. Soc. 2004, 126, 4528
• Cauble, D. F.; Gipson, J. D.; Krische, M. J. “Diastereo- and Enantioselective Catalytic Carbometallative Aldol Cycloreduction: Tandem Conjugate Addition- Aldol Cyclization,” J. Am. Chem. Soc. 2003, 125, 1110
• Cauble, D. F.; Lynch, V.; Krische, M. J. “Studies on the Enantioselective Catalysis of Photochemically Promoted Transformations: “Sensitizing Receptors” as Chiral Catalysts,” J. Org. Chem. 2003, 68, 15
• Huddleston, R. R.; Cauble, D. F.; Krische, M. J. “Borane-Mediated Aldol Cycloreduction of Mono-Enone Mono-Ketones: Diastereoselective Formation of Quaternary Centers,” J. Org. Chem. 2003, 68, 11
• Archer, E. A.; Cauble, D. F. Jr.; Lynch, V.; Krische, M. J. “Synthetic Duplex Oligomers: Optimizing Interstrand Affinity in a Synthetic Duplex Dimer through the use of a Noncovalent Constraint,” Tetrahedron 2002, 58, 721
• Cauble, D. F., Jr.; Krische, M. J. “The First Direct and Enantioselective Cross-Aldol Reaction of Aldehydes,” Chemtracts 2002, 15, 380